Dow Jones
52,486.49
Change
+254.6+0.49%
52-Week Top Losing U.S. stocks
Track U.S. stocks with the largest price declines over the past 52 weeks on MEXC. Stocks are ranked by 52-week percentage change from lowest to highest.
Market Overview
U.S. stocks are mixed today. The Dow Jones is +0.49%, the S&P 500 is +1.31%, and the Nasdaq Composite is +1.60%. Across individual stocks, 263 are advancing while 4,827 are declining, suggesting a mixed market tone.
S&P 500
7,619.38
Change
+98.45+1.31%
Nasdaq Composite
25,466.189
Change
+400.315+1.60%
24H Gainers
263
24H Losers
4,827
52 Week Losers
| # | Stock | 52 Week Range | |||||
|---|---|---|---|---|---|---|---|
| 501 | Shuttle Pharmaceuticals Holdings, Inc.SHPH | $5.26 | -2.77% | 12.83K | $25.09M | $2.58 - $44.40 | 0.00% |
| 502 | Defi Technologies, Inc.DEFT | $0.34 | +1.82% | 9.76K | $130.48M | $0.30 - $1.73 | 0.00% |
| 503 | TEN Holdings, Inc.XHLD | $0.85 | +0.12% | 14.00K | $10.50M | $0.38 - $15.43 | 0.00% |
| 504 | Aptera Motors Corp.SEV | $1.56 | -0.89% | 955 | $93.33M | $1.29 - $8.30 | 0.00% |
| 505 | Creative Medical Technology Holdings, Inc.CELZ | $0.63 | 0.00% | 3.41K | $4.15M | $0.59 - $4.72 | 0.00% |
| 506 | Maris-Tech Ltd.MTEK | $0.28 | +6.15% | 343.13K | $2.67M | $0.21 - $2.82 | 0.00% |
| 507 | Globavend Holdings LimitedGVH | $0.94 | +3.87% | 3.77K | $4.05M | $0.77 - $6.46 | 0.00% |
| 508 | Vistance Networks, Inc.VISN | $4.03 | -0.35% | 424 | $929.42M | $3.90 - $19.95 | 1.38% |
| 509 | Rocket One Inc.RKTO | $0.36 | -2.96% | 12.81K | $8.96M | $0.33 - $2.45 | 0.00% |
| 510 | PTIX | $0.00 | 0.00% | 0 | $0 | $0.13 - $2.38 | 0.00% |
| 511 | Acurx Pharmaceuticals, Inc.ACXP | $1.06 | +0.95% | 9.34K | $5.92M | $0.95 - $7.54 | 0.00% |
| 512 | AI Financial CorporationAIFC | $0.18 | -2.13% | 34.53K | $25.73M | $0.16 - $1.08 | 0.00% |
| 513 | DNA X, Inc.SONM | $2.35 | +0.21% | 10.89K | $3.50M | $2.02 - $11.16 | 0.00% |
| 514 | BridgeBio Oncology Therapeutics, Inc.BBOT | $2.71 | +7.98% | 3.08K | $184.40M | $1.98 - $14.87 | 0.00% |
| 515 | Smartbird, Inc.BIRD | $1.27 | +1.60% | 12.34K | $11.82M | $1.21 - $24.31 | 0.00% |
| 516 | Eightco Holdings Inc.ORBS | $0.72 | -1.37% | 20.02K | $301.98M | $0.57 - $3.67 | 0.00% |
| 517 | Exascale Labs Holdings Inc.XLAB | $1.10 | +5.74% | 68.68K | $72.05M | $0.78 - $7.39 | 0.00% |
| 518 | Lightbridge Corp.LTBR | $4.35 | -2.92% | 3.31K | $163.09M | $3.91 - $20.85 | 0.00% |
| 519 | enCore Energy Corp.EU | $0.58 | -2.68% | 69.12K | $113.55M | $0.56 - $3.67 | 0.00% |
| 520 | Lucid Group, Inc.LCID | $3.60 | -0.41% | 152.82K | $1.42B | $2.37 - $16.82 | 0.00% |
| 521 | BioHarvest Sciences Inc.BHST | $1.72 | 0.00% | 3 | $28.25M | $1.37 - $8.30 | 0.00% |
| 522 | SL Science Holding LimitedSLBT | $0.73 | -2.42% | 2.28K | $548.65M | $0.62 - $14.50 | 0.00% |
| 523 | ASP Isotopes Inc.ASPI | $1.94 | -1.48% | 46.94K | $296.81M | $1.66 - $9.19 | 0.00% |
| 524 | York Space Systems Inc.YSS | $7.35 | -0.62% | 10.77K | $976.61M | $5.26 - $44.54 | 0.00% |
| 525 | Byrna Technologies, Inc.BYRN | $3.94 | -6.97% | 233 | $92.10M | $3.17 - $20.69 | 0.00% |
| 526 | Teads Holding CoTEAD | $0.18 | 0.00% | 23 | $17.46M | $0.16 - $1.42 | 0.00% |
| 527 | enGene Therapeutics Inc.ENGN | $1.91 | +4.04% | 647.84K | $127.67M | $1.40 - $12.25 | 0.00% |
| 528 | Dermata Therapeutics, Inc.DRMA | $0.69 | -0.72% | 668 | $3.40M | $0.60 - $4.66 | 0.00% |
| 529 | Xanadu Quantum Technologies LimitedXNDU | $2.53 | -1.94% | 150.82K | $876.65M | $2.34 - $42.44 | 0.00% |
| 530 | Aurelion Inc.AURE | $1.02 | -1.83% | 139 | $19.75M | $0.85 - $5.48 | 0.00% |
| 531 | Prairie Operating CoPROP | $0.38 | +2.68% | 553 | $43.20M | $0.32 - $2.55 | 0.00% |
| 532 | Atlas Critical Minerals CorporationATCX | $1.96 | +7.16% | 0 | $8.66M | $1.83 - $14.01 | 0.00% |
| 533 | Locafy LimitedLCFY | $0.88 | +1.00% | 8.14K | $1.98M | $0.85 - $6.20 | 0.00% |
| 534 | RenX Enterprises Corp.RENX | $1.13 | -9.74% | 79 | $3.93M | $0.84 - $7.00 | 0.00% |
| 535 | Tonix Pharmaceuticals Holding Corp.TNXP | $3.97 | +1.64% | 7.76K | $68.07M | $3.78 - $20.56 | 0.00% |
| 536 | DocGo Inc.DCGO | $0.24 | +2.10% | 5 | $24.04M | $0.21 - $1.11 | 0.00% |
| 537 | Oklo Inc.OKLO | $25.00 | -3.36% | 201.92K | $4.65B | $18.54 - $116.98 | 0.00% |
| 538 | GT Biopharma Inc.GTBP | $4.10 | +3.20% | 12 | $8.45M | $3.83 - $28.75 | 0.03% |
| 539 | Full House Resorts, Inc.FLL | $0.59 | -0.17% | 21 | $21.40M | $0.57 - $3.37 | 0.00% |
| 540 | Kestrel Group, Ltd.KG | $3.83 | -1.77% | 0 | $35.82M | $3.74 - $17.44 | 0.00% |
| 541 | Filana Therapeutics, Inc.FLNA | $0.48 | -2.85% | 5.22K | $23.98M | $0.43 - $2.27 | 0.00% |
| 542 | BitGo Holdings, Inc.BTGO | $4.23 | -2.75% | 8.79K | $599.48M | $4.14 - $24.50 | 0.00% |
| 543 | Cerenome, Inc.CNSY | $0.81 | -1.71% | 15.19K | $6.12M | $0.43 - $4.25 | 0.00% |
| 544 | Lexaria Bioscience Corp.LEXX | $3.93 | -12.46% | 52 | $8.28M | $2.43 - $21.60 | 0.00% |
| 545 | Nakamoto Inc.NAKA | $6.17 | -1.37% | 3.83K | $113.27M | $3.33 - $29.34 | 0.00% |
| 546 | NervGen Pharma Corp.NGEN | $1.38 | +1.02% | 255.81K | $111.27M | $1.28 - $6.30 | 0.00% |
| 547 | CollPlant Biotechnologies LtdCLGN | $4.37 | +10.66% | 10.40K | $8.26M | $2.64 - $22.50 | 0.00% |
| 548 | Enveric Biosciences, Inc.ENVB | $1.39 | -5.37% | 5 | $6.23M | $1.17 - $13.25 | 0.00% |
| 549 | MIND Technology, Inc.MIND | $3.15 | -0.29% | 123 | $28.61M | $3.01 - $14.50 | 0.00% |
| 550 | aTyr Pharma, Inc.ATYR | $6.74 | -0.01% | 87 | $19.32M | $4.07 - $44.40 | 0.00% |
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Frequently Asked Questions (FAQ)
What are 52-week top losing U.S. stocks?
These are U.S. stocks that have recorded some of the largest price declines over the past 52 weeks.
How is the 52-week decline measured?
It compares the latest available stock price with its price around 52 weeks earlier and calculates the percentage change.
Which stock has fallen the most over 52 weeks?
Shuttle Pharmaceuticals Holdings, Inc. (SHPH) currently shows a 52-week decline of 79.02% as of 2026-11-12 13:49 UTC.
Why track 52-week stock losers?
The ranking helps identify stocks facing prolonged price weakness and provides a starting point for further company and valuation research.
Is a 52-week loser automatically a value stock?
No. A lower stock price does not necessarily mean a company is undervalued, so valuation and fundamental data should be reviewed separately.
How is this different from Top Losers?
52-Week Losers measures longer-term performance, while Top Losers focuses on shorter-term market declines.
Discover Top US Stocks
Apple Inc.AAPLAlphabet Inc.GOOGBroadcom Inc.AVGOBerkshire Hathaway Inc.BRK.AVISA Inc.VABBVIE INC.ABBVApple Inc.AAPLAlphabet Inc.GOOGBroadcom Inc.AVGOBerkshire Hathaway Inc.BRK.AVISA Inc.VABBVIE INC.ABBVApple Inc.AAPLAlphabet Inc.GOOGBroadcom Inc.AVGOBerkshire Hathaway Inc.BRK.AVISA Inc.VABBVIE INC.ABBVApple Inc.AAPLAlphabet Inc.GOOGBroadcom Inc.AVGOBerkshire Hathaway Inc.BRK.AVISA Inc.VABBVIE INC.ABBV
Apple Inc.AAPLAlphabet Inc.GOOGBroadcom Inc.AVGOBerkshire Hathaway Inc.BRK.AVISA Inc.VABBVIE INC.ABBVApple Inc.AAPLAlphabet Inc.GOOGBroadcom Inc.AVGOBerkshire Hathaway Inc.BRK.AVISA Inc.VABBVIE INC.ABBVApple Inc.AAPLAlphabet Inc.GOOGBroadcom Inc.AVGOBerkshire Hathaway Inc.BRK.AVISA Inc.VABBVIE INC.ABBVApple Inc.AAPLAlphabet Inc.GOOGBroadcom Inc.AVGOBerkshire Hathaway Inc.BRK.AVISA Inc.VABBVIE INC.ABBV
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Microsoft Corp.MSFTSpace Exploration Technologies Corp.SPCXEli Lilly & Co.LLYAdvanced Micro DevicesAMDExxon Mobil CorporationXOMCoca-Cola CompanyKOMicrosoft Corp.MSFTSpace Exploration Technologies Corp.SPCXEli Lilly & Co.LLYAdvanced Micro DevicesAMDExxon Mobil CorporationXOMCoca-Cola CompanyKOMicrosoft Corp.MSFTSpace Exploration Technologies Corp.SPCXEli Lilly & Co.LLYAdvanced Micro DevicesAMDExxon Mobil CorporationXOMCoca-Cola CompanyKOMicrosoft Corp.MSFTSpace Exploration Technologies Corp.SPCXEli Lilly & Co.LLYAdvanced Micro DevicesAMDExxon Mobil CorporationXOMCoca-Cola CompanyKO
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Disclaimer
US stock prices, indices, rankings, charts, and other market data displayed on this page may be sourced from third-party providers and may be delayed or inaccurate. MEXC provides this information for informational and educational purposes only and does not guarantee its accuracy or completeness. Nothing on this page constitutes financial or investment advice or a recommendation to buy or sell any security. US stock trading involves risk, and past performance does not guarantee future results. Users should conduct independent research before making investment decisions.